{"id":471,"date":"2021-08-05T19:27:08","date_gmt":"2021-08-05T19:27:08","guid":{"rendered":"https:\/\/research.phys.cmu.edu\/deserno\/?page_id=471"},"modified":"2021-08-06T20:22:16","modified_gmt":"2021-08-06T20:22:16","slug":"science","status":"publish","type":"page","link":"https:\/\/research.phys.cmu.edu\/deserno\/science\/","title":{"rendered":"Science"},"content":{"rendered":"<p><div class=\"et_d4_element et_pb_section et_pb_section_0  et_pb_css_mix_blend_mode et_pb_fullwidth_section et_section_regular et_block_section\" >\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_fullwidth_slider_0 et_pb_slider\">\n\t\t\t\t<div class=\"et_pb_slides\">\n\t\t\t\t\t<div class=\"et_d4_element et_pb_slide et_pb_slide_0  et_pb_css_mix_blend_mode et_pb_bg_layout_dark et_pb_media_alignment_center et-pb-active-slide\" data-slide-id=\"et_pb_slide_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_container clearfix\">\n\t\t\t\t\t<div class=\"et_pb_slider_container_inner\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"et_pb_slide_description\">\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><div class=\"et_d4_element et_pb_section et_pb_section_1  et_pb_css_mix_blend_mode et_section_regular et_block_section\" >\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_d4_element et_pb_row et_pb_row_0  et_pb_css_mix_blend_mode et_block_row\">\n\t\t\t\t<div class=\"et_d4_element et_pb_column_4_4 et_pb_column et_pb_column_0  et_pb_css_mix_blend_mode et-last-child et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_text et_pb_text_0  et_pb_text_align_left et_pb_bg_layout_light\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_text_inner\"><h2 style=\"text-align: justify\"><span>Current Research<\/span><\/h2><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><div class=\"et_d4_element et_pb_row et_pb_row_1  et_pb_css_mix_blend_mode et_block_row\">\n\t\t\t\t<div class=\"et_d4_element et_pb_column_4_4 et_pb_column et_pb_column_1  et_pb_css_mix_blend_mode et-last-child et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_text et_pb_text_1  et_pb_text_align_left et_pb_bg_layout_light\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_text_inner\"><p style=\"text-align: justify\"><span>Our current research focuses on physical problems that occur in the context of molecular cell biology. We are particularly interested in lipid membranes and proteins and their mutual interactions, but we also work on a fair number of other related topics. Our main tools are computer simulations and analytical theory, and in both cases we try to devise simplified descriptions that capture the (presumed) essence of the physical situation while eliminating most of the (presumably) unnecessary detail.<\/span><\/p>\n<p style=\"text-align: justify\"><span>Presently, a problem of considerable focus is membrane asymmetry\u2014<em>i.e.<\/em>, the question what happens when the two leaflets making up a lipid bilayer membrane differ in at least one important aspect.<\/span><\/p><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><div class=\"et_d4_element et_pb_row et_pb_row_2  et_pb_css_mix_blend_mode et_block_row\">\n\t\t\t\t<div class=\"et_d4_element et_pb_column_4_4 et_pb_column et_pb_column_2  et_pb_css_mix_blend_mode et-last-child et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_text et_pb_text_2  et_pb_text_align_left et_pb_bg_layout_light\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_text_inner\"><h2>Science notes<\/h2><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><div class=\"et_d4_element et_pb_row et_pb_row_3  et_pb_css_mix_blend_mode et_block_row\">\n\t\t\t\t<div class=\"et_d4_element et_pb_column_1_4 et_pb_column et_pb_column_3  et_pb_css_mix_blend_mode et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_image et_pb_image_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap has-box-shadow-overlay\"><div class=\"box-shadow-overlay\"><\/div><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"http:\/\/research.phys.cmu.edu\/deserno\/wp-content\/uploads\/sites\/6\/2021\/08\/Science-notes-image-1.png\" alt=\"\" title=\"Science-notes-image-1\" srcset=\"https:\/\/research.phys.cmu.edu\/deserno\/wp-content\/uploads\/sites\/6\/2021\/08\/Science-notes-image-1.png 300w, https:\/\/research.phys.cmu.edu\/deserno\/wp-content\/uploads\/sites\/6\/2021\/08\/Science-notes-image-1-150x150.png 150w\" sizes=\"(max-width: 300px) 100vw, 300px\" class=\"wp-image-485\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_d4_element et_pb_column_3_4 et_pb_column et_pb_column_4  et_pb_css_mix_blend_mode et-last-child et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_accordion et_pb_accordion_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_toggle et_pb_module et_d4_element et_pb_accordion_item et_pb_accordion_item_0  et_pb_toggle_open\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<h5 class=\"et_pb_toggle_title\">Notes on differential geometry<\/h5>\n\t\t\t\t<div class=\"et_pb_toggle_content clearfix\"><p style=\"text-align: justify\"><a href=\"https:\/\/www.cmu.edu\/biolphys\/deserno\/pdf\/diff_geom.pdf\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"http:\/\/research.phys.cmu.edu\/deserno\/wp-content\/uploads\/sites\/6\/2021\/08\/PDF_file_icon.png\" width=\"45\" style=\"float: left;padding: 0px 10px 0px 0px\" \/><\/a>These notes are an attempt to summarize some of the key mathematical aspects of differential geometry, as they apply in particular to the geometry of two-dimensional surfaces embedded in three-dimensional Euclidean space. The focus is not on mathematical rigor but rather on collecting some bits and pieces of the very powerful machinery of manifolds and \u201cpost-Newtonian calculus\u201d. Download the pdf here.<\/p><\/div>\n\t\t\t<\/div><div class=\"et_pb_toggle et_pb_module et_d4_element et_pb_accordion_item et_pb_accordion_item_1  et_pb_toggle_close\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<h5 class=\"et_pb_toggle_title\">Notes on membrane theory<\/h5>\n\t\t\t\t<div class=\"et_pb_toggle_content clearfix\"><p style=\"text-align: justify\"><a href=\"https:\/\/www.cmu.edu\/biolphys\/deserno\/pdf\/membrane_theory.pdf\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"http:\/\/research.phys.cmu.edu\/deserno\/wp-content\/uploads\/sites\/6\/2021\/08\/PDF_file_icon.png\" width=\"45\" style=\"float: left;padding: 0px 10px 0px 0px\" \/><\/a>These notes offer a very brief primer on some essential theoretical concepts pertaining to lipid membrane physics. They cover a few aspects of lipid self assembly, elementary membrane elasticity, an introduction to the geometry of surface curvature, and the basics of Helfrich theory. These notes have been prepared for a summer school attended by both theorists and experimentalists, and they are purposefully kept at an introductory level.<\/p><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><div class=\"et_d4_element et_pb_row et_pb_row_4  et_pb_css_mix_blend_mode et_block_row\">\n\t\t\t\t<div class=\"et_d4_element et_pb_column_4_4 et_pb_column et_pb_column_5  et_pb_css_mix_blend_mode et-last-child et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_text et_pb_text_3  et_pb_text_align_left et_pb_bg_layout_light\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_text_inner\"><h2>Random Acts of Knowledge<\/h2><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><div class=\"et_d4_element et_pb_row et_pb_row_5  et_pb_css_mix_blend_mode et_block_row\">\n\t\t\t\t<div class=\"et_d4_element et_pb_column_1_4 et_pb_column et_pb_column_6  et_pb_css_mix_blend_mode et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_image et_pb_image_1\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<a href=\"https:\/\/research.phys.cmu.edu\/deserno\/random-acts-of-knowledge\/\"><span class=\"et_pb_image_wrap has-box-shadow-overlay\"><div class=\"box-shadow-overlay\"><\/div><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"200\" src=\"http:\/\/research.phys.cmu.edu\/deserno\/wp-content\/uploads\/sites\/6\/2021\/08\/RAoK-image.png\" alt=\"\" title=\"RAoK-image\" srcset=\"https:\/\/research.phys.cmu.edu\/deserno\/wp-content\/uploads\/sites\/6\/2021\/08\/RAoK-image.png 400w, https:\/\/research.phys.cmu.edu\/deserno\/wp-content\/uploads\/sites\/6\/2021\/08\/RAoK-image-300x150.png 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" class=\"wp-image-484\" \/><\/span><\/a>\n\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_d4_element et_pb_column_3_4 et_pb_column et_pb_column_7  et_pb_css_mix_blend_mode et-last-child et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_text et_pb_text_4  et_pb_text_align_left et_pb_bg_layout_light\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_text_inner\"><p style=\"text-align: justify\"><span>Over time I have established a somewhat (but not completely) \"random\" collection of scientific notes on topics which I came across at some point. The idea was to preserve some essential insights in a semi-polished fashion, such as to be able to access it quickly and efficiently later. If you're interested, you're very welcome to rummage in my science-attic! In that case, <strong><span style=\"color: #339966\"><a href=\"https:\/\/research.phys.cmu.edu\/deserno\/random-acts-of-knowledge\/\" style=\"color: #339966\">please enter here<\/a><\/span><\/strong>!<\/span><\/p><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><div class=\"et_d4_element et_pb_row et_pb_row_6  et_pb_css_mix_blend_mode et_block_row\">\n\t\t\t\t<div class=\"et_d4_element et_pb_column_4_4 et_pb_column et_pb_column_8  et_pb_css_mix_blend_mode et-last-child et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_text et_pb_text_5  et_pb_text_align_left et_pb_bg_layout_light\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_text_inner\"><h2>Fun stuff<\/h2><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><div class=\"et_d4_element et_pb_row et_pb_row_7  et_pb_css_mix_blend_mode et_block_row\">\n\t\t\t\t<div class=\"et_d4_element et_pb_column_1_4 et_pb_column et_pb_column_9  et_pb_css_mix_blend_mode et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_image et_pb_image_2\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap has-box-shadow-overlay\"><div class=\"box-shadow-overlay\"><\/div><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"http:\/\/research.phys.cmu.edu\/deserno\/wp-content\/uploads\/sites\/6\/2021\/08\/Fun-stuff-image.png\" alt=\"\" title=\"Fun-stuff-image\" srcset=\"https:\/\/research.phys.cmu.edu\/deserno\/wp-content\/uploads\/sites\/6\/2021\/08\/Fun-stuff-image.png 300w, https:\/\/research.phys.cmu.edu\/deserno\/wp-content\/uploads\/sites\/6\/2021\/08\/Fun-stuff-image-150x150.png 150w\" sizes=\"(max-width: 300px) 100vw, 300px\" class=\"wp-image-483\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_d4_element et_pb_column_3_4 et_pb_column et_pb_column_10  et_pb_css_mix_blend_mode et-last-child et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_text et_pb_text_6  et_pb_text_align_left et_pb_bg_layout_light\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_text_inner\"><ul>\n<li>Paper model for folding your own CCMV virus [<span style=\"color: #333399\"><a href=\"https:\/\/www.cmu.edu\/biolphys\/deserno\/pdf\/CCMV.pdf\" target=\"_blank\" rel=\"noopener\" style=\"color: #333399\">pdf<\/a><\/span>]<\/li>\n<\/ul><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-471","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/research.phys.cmu.edu\/deserno\/wp-json\/wp\/v2\/pages\/471","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.phys.cmu.edu\/deserno\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.phys.cmu.edu\/deserno\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.phys.cmu.edu\/deserno\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/research.phys.cmu.edu\/deserno\/wp-json\/wp\/v2\/comments?post=471"}],"version-history":[{"count":21,"href":"https:\/\/research.phys.cmu.edu\/deserno\/wp-json\/wp\/v2\/pages\/471\/revisions"}],"predecessor-version":[{"id":539,"href":"https:\/\/research.phys.cmu.edu\/deserno\/wp-json\/wp\/v2\/pages\/471\/revisions\/539"}],"wp:attachment":[{"href":"https:\/\/research.phys.cmu.edu\/deserno\/wp-json\/wp\/v2\/media?parent=471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}